Driving the Amyloid Cascade? A microglial subtype, Mic.12, promotes plaque deposition, while another, Mic.13, promotes tangles. An astrocyte subtype, Ast.10, contributes to cognitive decline, as well ...

About two-thirds of people with Alzheimer’s disease are women, yet due to the challenges in studying X chromosomes, a genetic foundation for this has been difficult to uncover. Now, two large ...

This constitutive KI mouse model was generated by Flp-mediated homologous recombination in mouse embryonic stem cells to introduce an S65A point mutation in exon 3 of the Park2 (Parkin) gene ...

Two Types. Confocal microscopy reveals α-synuclein (green) and lipids (red) in three adjacent inclusions (left and right). The white arrows point to Type I inclusions loaded with lipids. Blue ...

PI and Co-founder International Group of Neuroscience, Neuroengineering and Neurophilosophy IGN(S,E,P) https://www.researchgate.net/lab/Juan-Fernando-Gomez-Molina-Lab ...

Immunotherapy can remove extracellular amyloid plaques from Alzheimer’s brain, but has so far failed to clear intracellular tau tangles. Now, two papers propose a solution: tagging them for ...

She co-leads that institution’s MODEL-AD core along with Bruce Lamb. MODEL-AD aims to create mouse models that reflect different biological subtypes of AD that have been found in people, in hopes of ...

Physician and Surgeon - Universidad de Antioquia, UA, Antioquia, Colombia. Doctor of Medicine – Magna cum laude - University of Hamburg, Hamburg, HH, Germany. PostDoc – Alzheimer’s Disease ...

But some 80 percent of people with Parkinson's disease have GI problems, such as acid reflux, irritable bowel syndrome, and constipation, which often emerge decades before motor difficulties do. This ...