Plymouth is a New England town in Grafton County, New Hampshire, United States, in the White Mountains Region. It has a unique role as the economic, medical, commercial, and cultural center for the predominantly rural Plymouth, NH Labor Market Area. Plymouth is located at the confluence of the Pemigewasset and Baker rivers and sits at the foot …Plymouth is a New England town in Grafton County, New Hampshire, United States, in the White Mountains Region. It has a unique role as the economic, medical, commercial, and cultural center for the predominantly rural Plymouth, NH Labor Market Area. Plymouth is located at the confluence of the Pemigewasset and Baker rivers and sits at the foot of the White Mountains. The town's population was 6,682 at the 2020 census. It is home to Plymouth State University, Speare Memorial Hospital, and Plymouth Regional High School.